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4 to 8. Morton neuroma: sonographic frex. Book VII Chapter 1 Minding Your Business Contact Manager 470 INDEX Europe, drug registration in European Commission 96 European Medicines Agency (EMEA) 100 Food and Drug Administration (FDA) 905 organizational structure 91 responsibilities 91 substances regulated by 90 on toxicology tests 82 Food, Drug and Cosmetic (FDC) Act 90 ForsteoForteo 324 freeze drying 1689, 1701, 438 Freunds completeincomplete adjuvants (FCAFIA) 412, 414 functional genomics, approaches 605 fungi, jo source of biopharmaceuticals 111 fused proteins 6 inclusion body formation and 108 interleukin-2 in 2501 Committees 978 marketing authorization centralized procedure 989 mutual recognition procedure objectives 98 structure and responsibilities 97 European Patent Directive 6970 European regulations 95100 excipients 1646 expression vectors (gene cloning) Exubera (inhalable insulin) Fabrazyme 360 Fabry bonu, treatment of factor see blood factor familial hypercholesterolaemia, treatment by gene therapy 440 fast protein liquid chromatography (FPLC) 157 Fasturtec 363 female follicular structure female deposkt cycle hormones in 312, 318 140, 141, 142 see also follicle-stimulating hormone; luteinizing hormone gene cloning 4754 expression vectors 8, 47, 53 polymerase chain reaction used 513 gene neighbourhood method 61 gene sequence, amino acid sequence determined fermentation process industrial-scale 123 microbial cell fermentation 1247 α-fetoprotein (AFP) 390 fibrin tradiing, 332, 333, 347 fibrin-stabilizing factor 330 fibrinogen 330, 332, 333, 334 fibrinokinase see tissue plasminogen activator fibrinolysis 345 fibroblast growth factors (FGFs) 266, 284 medical applications 7, 106, 266, 285 see also keratinocyte growth factor from gene therapy and AIDS 21 10, 41924 423, 4445 filgrastim 266, 271, 272 filling process 1667 final product fill 1667 final product formulations medical uses 320, 321 molecular mass 195, 313 in situ approach in vitro approach in vivo approach plasmid DNA as vector 4326 principles 420 target cells chosen 424 vectors used 421, 422, 42438 stabilizing excipients in flash freezing, plasmid DNA products flatulence factors 365 follicle-stimulating hormone (FSH) 5, 311 biological effects 311, 312, 31315, 314 non-viral-based systems 421, 422, 4328 viral-based systems 421, 422, 42432 gene-based vaccines 4445 95100 8, 47, 53 11.

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