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586 0. 1 Properties of Selected Growth Factors and Growth Factor Receptors Receptor Epidermal growth factor receptors Epidermal growth factor (EGFRErbB1HER1) EGFRErbB1HER1 EGFRErbB1HER1 EGFRErbB1HER1 EGFRErbB1HER1; ErbB4HER4 ErbB4HER4 ErbB4HER4 EGFR2ErbB2HER3 EGFR3ErbB2HER2 PDGFR PDGFRa and PDGFRb Fibroblast growth factor receptors (FGFR) 1,2,3,4 TGF-b IGFR IGF-1R IGF-1R, IGF-2R c-Met Ligand Epidermal growth factor Epidermal growth factor Transforming growth factor a (TGF-a) Amphiregulin Epigen Heparin binding (HB)-EGF Betacellulin Epiregulin No natural ligand identified Platelet-derived growth factors (PDGF) PDGFA, PDGFB, PDGFC, PDGFD Fibroblast growth factor 120 Transforming growth factor b family (TGF-b) Insulin-like growth factor IGF IGF-1 IGF-2 Hepatocyte growth factorscatter factor (HGFSF) Receptor Description Transmembrane tyrosine kinases acids in length, which are sometimes termed mitogens because they induce the cell to grow and divide (Table 11.
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